Protein function
Encodes an E3 ubiquitin ligase.
Phenotype
Remarks: VIM1 overexpressor has reduced root growth.
[Kraft et al., 2008] Single mutant: vim1 single mutant does not display any flowering-time phenotype.
[Woo et al., 2008] Remarks: vim1;
vim2;
vim3 multiple mutant shows increased
FWA expression levels.
[Woo et al., 2008] Multiple mutant: vim1;
vim2;
vim3 triple mutant is late flowering under LD conditions. ( No data available under SD conditions.)
[Woo et al., 2008] Remarks: Strangely, both
vim1;
vim2;
vim3 multiple mutant and
VIM1 overexpressor are late flowering, suggesting that those phenotypes are caused by different mechanisms.
[Woo et al., 2008] Function:E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Associates with methylated DNA, and can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. Probably acts at the DNA methylation?histone interface to maintain centromeric heterochromatin.
[Data from UniProt]
Regulators, targets and interactors
Downstream actors
Upstream actors
Protein-protein interactions